Drew Barrymore

Movie star at age 7. Drinker at 9. Drug user at 10. Rehabilitated bestselling memoirist at 14. The scion of an acting dynasty, Drew Barrymore rose above her early notoriety, transforming into a Hollywood power player as an actor and producer.

Steven Spielberg cast her in his 1982 classic E.T. The Extra-Terrestrial, and she soon became the youngest person ever to host Saturday Night Live. Through her company Flower Films, Barrymore has cultivated some of her most successful films (Charlie's Angels, Donnie Darko) herself.

Impulsive marriages to bar owner Jeremy Thomas and gross-out comedian Tom Green didn't last. Barrymore, who nabbed the title as PEOPLE's Most Beautiful in 2007, went on to date Strokes drummer Fabrizio Moretti and actor Justin Long.